Jia Ye.

Education & Academic Experience:

1990- 1993: Doctorate of Medicine in TCM, Shanghai University of Chinese Traditional medical, China, Dissertation: Treatment of gastric cancer with Chinese medicine in clinical and experimental.

1993-1995: Post doctor, Dept. of biochemistry and molecular biology, School of Basic Medical Sciences, Beijing University. Dissertation: Study of mechanism for the anti-cataract effect of traditional Chinese medicine.

1995-1997:  Research assistant, State Key Laboratory of Medical Molecular Biology Institute of Basic Medial Sciences Chinese Academy of Medical Sciences (Peking Union Medical College). Research subject: Study of activating gene in B lymphocyte.

1997-1998: Visiting scholar, of Japan longevity fund, Dept. of Immunopathology, WHO Tokyo Metropolitan Institute of Gerontology. Research subject: Study of the pathogenetic mechanism of autoimmune disease.

2000-   Associate professor, Dept. of pharmacology, School of Pharmaceutical Sciences, Beijing University.

Current Research Subject:

1. A novel peripheral antinociceptive and anti-inflammatory mechanism underlies acting peripheral a7 nicotinic and M4 muscarinic acetylcholine receptor.

2. Possible mechanism of immunosuppressive effect of Iminosugar.

3. Studies on efficacy and property of genuine and non genuine Chinese herbal medicine

4. Anti-aging effect and mechanism of traditional Chinese medicine.

Major Publication

1． Xia Zhao, Jia Ye*, Qi Sun, Yulan Xiong, Runtao Li and Yimin Jiang Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice   Neuropharmacology 2011, 60, 446-452.

2．Yulan Xiong, Xia Zhao, Qi Sun, Runtao Li, Changling Li, Jia Ye*，Antinociceptive mechanism of the spirocyclopiperazinium compound LXM-10 in mice and rats  Pharmacology, Biochemistry and Behavior 2010, 95, 192–197.

3． Yulan Xiong, Jia Ye*, Qi Sun, Xia Zhao, Runtao Li, Yimin Jiang, Anti-inflammatory effect of the spirocyclopiperazinium compound LXM-10 in mice and rats  European Journal of Pharmacology 2010, 626, 290–296.

4． Ji DB, Zhu MC, Zhu B, Zhu YZ, Li CL, Ye J*, Zhu HB  Hydroxysafflor yellow A enhances survival of vascular endothelial cells under hypoxia via upregulation of the HIF-1 alpha-VEGF pathway and regulation of Bcl-2/Bax.  J Cardiovasc Pharmacol  2008, 52, 191-202.

5． Deng Bo JI,  Hai Bo ZHU,  Jia YE*,  and Chang Ling LI    Establishment of a Cell-Based Assay to Screen Regulators of the Hypoxia-Inducible Factor-1-Dependent Vascular Endothelial Growth Factor promoter, Biol. Pharm. Bull. 2008, 31, 2255-2259.

6． Deng-Bo Ji, Jia Ye*, Chang-Ling Li, Yu-Hua Wang, Jiong Zhao and Shao-Qing Cai  Antiaging Effect of Cordyceps sinensis Extract  Phytotherapy Research 2009, 23, 116–122.

7． Deng Bo Jia,  Chang Ling Li, Jia Ye* and Hai Bo Zhu, Effect of Hydroxysafflor yellow A on Human Umbilical Vein Endothelial Cells under hypoxia  Vascular Pharmacology 2009, 50,137–145.

8．Deng-Bo Ji, Jia Ye*, Yi-Min Jiang and Bo-Wen Qian   Anti-tumor effect of Liqi, a traditional Chinese medicine prescription, in tumor bearing mice  BMC Complementary and Alternative Medicine, 2009, 9, 20.

9．Song-Wen Lin, Qi Sun, Ze-Mei Ge, Xin Wang, Jia Ye*, Run-Tao Li  Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ) Bioorganic & Medicinal Chemistry Letters 2011, 21, 940–943.

10．Guo-Liang Zhang, Changshui Chen, Yulan Xiong, Li-He Zhang, Jia Ye*，Xin-Shan Ye， Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities  Carbohydrate Research 2010 ,345, 780–786. 

11．Cai-Qin Yue, Jia Ye*, Chang-Ling Li, Run-Tao Li, Qi Sun, Antinociceptive effects of the novel spirocyclopiperazinium salt compound LXM -10 in mice, Pharmacology, Biochemistry and Behavior, 2007, 86, 643–650.

Patent：

Run-Tao Li, Qi Sun, Jia Ye, Cai-Qin Yue, Xin Wang, Ze-mei Ge, Chang-Ling Li, and Tie-Ming Cheng， Preparation and application of spirocyclopiperazinium salt compounds  WO(PTC/CN2007/00187)，filing date 2007,6,15.